df.drop(df.index[2])
>>> df A B C D 0 0 1 2 3 1 4 5 6 7 2 8 9 10 11 Drop a row by index df.drop([0, 1]) A B C D 2 8 9 10 11 Drop columns df.drop(columns=['B', 'C']) A D 0 0 3 1 4 7 2 8 11